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Therefore, we conclude that 5FU promotes metabolic reprogramming in drug-tolerant cells, increasing mitochondrial activity supported by an acute increase in metabolic gene transcription

For example, hypomethylating agents promote GSDME-mediated pyroptosis, while the p53 reactivator APR-246 induces ferroptosis, suggesting that the partial therapeutic efficacy of these agents may stem from non-apoptotic death mechanisms (14,158)

In the first one to two days after treatment, mild fatigue or slight headaches may occasionally occur

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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Owens J.A., Mindell J., Baylor A