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95 g Fmoc-Gly-2-CTC Resin (20 mmol) with a degree of substitution of 0.211 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt

Patients who are pregnant, nursing, or have certain conditions (such as pancreatitis, gallbladder disease, or thyroid cancer) may not be eligible

Appetite reduction lowers calorie intake, and lower calorie intake often reduces protein intake unless nutrition is intentionally structured

The MHRA-approved product information does not list heavy menstrual bleeding as a recognised adverse effect of Ozempic

The most noticeable weight changes usually appear within the first few months of treatment