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Panopoulos, A.D., et al.,The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10

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