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For nivolumab and pembrolizumab, 43.15% and 37.76% of reports originated from the United States, whereas higher proportions of reports for atezolizumab and durvalumab were submitted from Japan (27.4% and 29.1%)

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Changes in relative mRNA expression for genes encoding enzymes involved in ascorbic acid degradation and recycling during fruit development, including AO1, AO2, APX1, APX2, APX3, GR1, GR2, MDHAR, DHAR1, and DHAR2

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Serine availability is derived from exogenous dietary uptake and endogenous synthesis via the serine synthesis pathway (SSP), which depends on glycolytic intermediates