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Abbreviations -SMA: Alpha-Smooth Muscle Actin ACC: Acetyl-CoA Carboxylase AFLD: Alcoholic Fatty Liver Disease ALD: Alcohol-Associated Liver Disease ALI: Acute Lung Injury ALT: Alanine Aminotransferase AMPK: Adenosine Monophosphate-Activated Protein Kinase AREs: Antioxidant Responsive Elements ASH: Alcoholic Steatohepatitis AST: Aspartate Aminotransferase CCL4: Carbon Tetrachloride 4 CD: Cluster of Differentiation ChoRE: Carbohydrate Response Element ChREBP: Carbohydrate Response Element Binding Protein CO: Carbon Monoxide CPT1: Carnitine Palmitoyltransferase 1 DAMPs: Damage-Associated Molecular Patterns DNL: De Novo Lipogenesis ECM: Extracellular Matrix ERS: Endoplasmic Reticulum Stress FAO: Fatty Acid Oxidation FASN: Fatty Acid Synthase FFA: Free Fatty Acid G6PD: Glucose-6-Phosphate Dehydrogenase GRP78: Glucose-Regulated Protein 78 GSH: Glutathione HCC: Hepatocellular Cancer HFD: High-Fat Diet HO-1: Heme Oxygenase-1 HSC: Hepatic Stellate Cell IL-6: Interleukin-6 IB: Inhibitor of B JAZF1: Juxtaposed with Another Zinc Finger Protein 1 Keap1: Kelch-Like ECH-Associated Protein 1 LKB1: Liver Kinase B1 LPS: Lipopolysaccharide M1: Macrophage 1 MASH: Metabolic dysfunction-Associated Steatohepatitis MASLD: Metabolic dysfunction-Associated Steatotic Liver Disease MFN2: Mitofusin 2 NA: Nicotinic acid NAD + : Nicotinamide Adenine Dinucleotide NADH: Nicotinamide Adenine Dinucleotide (reduced form) NAM: Nicotinamide NAMN: Nicotinic Acid Mononucleotide NAMPT: Nicotinamide Phosphoribosyltransferase NASH: Non-Alcoholic Steatohepatitis NF-B: Nuclear Factor-B NMN: Nicotinamide Mononucleotide NMNAT: Nicotinamide Mononucleotide Adenylyltransferase NMNH: Nicotinamide Mononucleotide Hydrogen NNMT: Nicotinamide N-Methyltransferase NO: Nitric Oxide NR: Nicotinamide Riboside NRF2: Nuclear Factor Erythroid 2-Related Factor 2 NRH: Dihydronicotinamide Riboside NSDP: Nisoldipine Derivative PARP1: Poly (ADP-Ribose) Polymerase 1 PGC-1: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha PPAR: Peroxisome Proliferator-Activated Receptor Alpha QAPRT: Quinolinic Acid Phosphoribosyltransferase RAGE: Receptor for Advanced Glycation End Products ROS: Reactive Oxygen Species SARM1: Sterile Alpha and TIR Motif Containing 1 SOD: Superoxide Dismutase SREBP-1c: Sterol Regulatory Element Binding Protein-1c TCA: Tricarboxylic Acid TG: Triglycerides TLR4: Toll-Like Receptor 4 TNF-: Tumor Necrosis Factor-Alpha UPR: Unfolded Protein Response References Abd-Allah H, Nasr M, Ahmed-Farid OAH, Ibrahim BMM, Bakeer RM, Ahmed RF

Figure 1 The safety profile of GLP-1 receptor agonists has been evaluated in several meta-analyses

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Eur Child Adolesc Psychiatry 19:83105

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