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thus, it may induce hypoglycemia and it is contraindicated in patients with advanced liver insufficiency.66 In contrast, the pharmacodynamics of nateglinide is not altered in patients with CLD and is thus expected to be safer.67 Incretin-based therapies Incretin-based therapies comprise injectable glucagon-like peptide-1 (GLP-1) receptor agonists and oral inhibitors of dipeptidylpeptidase-4 (DPP-4)(gliptins)

Discussion Creatine and GSH, two metabolites of glycine, are abundant in animal tissues and exert crucial physiological functions by supporting antioxidative capacity and energy metabolism [1]

This data was vital for regulatory approval and understanding the broader physiological effects of GLP-1 receptor agonist drugs

The role of PYY in pancreatic islet physiology and surgical control of diabetes

Brain Res 1990;535:1558.ArticlePubMed 5