The reduction in adiposity may help protect muscle tissue from muscle wasting, which is often seen in obesity-associated catabolic states [28], in addition, sustained negative energy balance promotes fat loss, but also contributes to lean tissue catabolism
Do not attempt to manage a missed dose independently or double-dose to compensate
Calibrate Built around behaviour change and metabolic coaching, Calibrate offers strong education but requires a year-long commitment and a higher upfront cost
Patients should maintain regular contact with their healthcare provider during this initial period to address concerns, adjust lifestyle strategies, and ensure appropriate progression through the dose escalation schedule
Lean tissue accounted for approximately 39% of total weight lost (Wilding et al., NEJM , 2021)