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GLP-1RAs reduce glycemia in patients with T2DM by increasing glucose-induced insulin secretion and inhibiting glucagon secretion via the stimulation of pancreatic GLP1 receptors in beta and alpha cells and by increasing insulin sensitivity [5]

This approach is not intended to diminish enthusiasm for underexplored peptide systems, but rather to strengthen the case for their systematic and responsible re-evaluation using modern tools

As inflammation plays a crucial role in the pathogenesis of various chronic conditions, including type 2 diabetes, cardiovascular disease, and autoimmune disorders, understanding the anti-inflammatory properties of GLP-1 could pave the way for novel therapeutic approaches

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some clinical trials of such treatments are currently underway (see clinicaltrials.gov/)