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It is hoped that further research will identify specific causes that lead to effective treatments

Further investigation is needed to determine the therapys effects on OA disease process and joint structure

The analysis of the optimized structures of the MichaelisMenten complex indicate that the polar residues at position 13 (Cys or Ser) stabilize the deprotonated GS , which in turn acts as the catalytic Brnsted base and abstracts the proton at position C2 of substrate 7 (Extended Data Fig

In the present study, we investigated the effects of glutathione loss-induced oxidative stress on brain pathologies