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While tirzepatide can improve cardiometabolic risk factors such as weight, blood pressure, and lipid profiles, the concurrent use of anabolic steroids may counteract these improvements and compound overall cardiovascular risk, particularly in individuals with pre-existing heart disease or multiple risk factors

As stated in FDA prescribing information, semaglutide should not be restarted after a confirmed pancreatitis episode, and alternative diabetes or weight management strategies should be pursued

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