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They typically cost around 50% less than the branded biologic at launch, compared to the 8090% cost reduction typical of small-molecule generics

Hulgan and Gerschenson, 2012)

In order to make GLP-1 better used in the clinic, drug developers modified its structure and developed a series of GLP-1R agonists ( GLP-1, a 30- or 31-amino-acid-long peptide hormone, is a gastrointestinal peptide secreted by the intestinal tract that potentiates insulin release and reduces glucagons concentration in physiological conditions ( Scheme 1

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Nevertheless, research shows that it works by inducing the release of two important skin proteins: collagen and decorin [2]