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Key cytokine mediators Mechanistically, IL-8 (CXCL8) acts as a central chemotactic and activating ligand, engaging CXCR1/2 receptors on neutrophils to drive directed migration, degranulation, and integrin-mediated adhesion to vascular endothelium
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130 Angiogenesis is a critical process involving the formation of new blood vessels that supply cancer cells with essential oxygen and nutrients, establishing the material foundation for tumor growth and creating pathways for tumor cell invasion and metastasis
DBP: Diastolic blood pressure, SBP: Systolic blood pressure, SHR: Spontaneously hypertensive rats, MBP: Mean blood pressure, NO: Nitric oxide
