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Do not combine different peptides in the same syringe or the same vial

The safety and antitumor roles of APR-246 were already investigated in a phase I/IIa clinical trial of patients with leukemia, lymphoma or prostate cancer and presented a favorable toxicity profile in patients with p53 mutation, while no clinical response was observed in patients with wild-type p53, according to the predefined response criteria [47, 48], which nicely corroborates the mechanism proposed here and its relevance for future clinical approaches

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We tested this idea using genetic and pharmacological inhibition of TS activity

But what truly surprised me was how she went beyond just the treatment