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While early anecdotal evidence suggested significant clinical symptomatic improvements, the five clinical trials identified in a recent meta-analysis used small populations with different clinical syndromes, measured different outcomes, and yielded no overall evidence of benefit [109]

Its active compound, curcumin, helps lower inflammation throughout the body, including the gut, which can be beneficial for pets suffering from chronic histamine intolerance

The improvement is attributed to the sustained release of melatonin and targeted delivery to the brain resulting in increased therapeutic efficacy compared to bare melatonin

Then, these cells were fixed the next day with 4% formaldehyde (Sigma-Aldrich, USA) for 10 min