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These numbers should be interpreted cautiously given the different trial designs, but the trend is consistent across multiple analyses

Fluorescence image of DCDNO2 (10 M) in HepG2 cells after 40 min of incubation (left image) and the fluorescence image of HepG2 cells after pretreatment with Baicalin (100 mM) for 30 m and with DCDNO2 (10 M) for 40 min (right image)

Since these food supplements and food products have not gone through the evaluation process of the FDA, the agency cannot assure its quality and safety

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Third, although protective effects were observed in preclinical models, their applicability to human OA remains uncertain, and well-designed clinical trials are necessary to validate these findings