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GSTP1 forms a complex with TRAF2 and thereby prevents the formation of TNF--induced TRAF2-ASK1 complex and therefore suppresses the activation of apoptosis signal-regulated kinase 1 (ASK1) [65]

Furthermore, there are drug interactions, particularly noted among online communities like Longecity, against the concurrent use of FOXO4-DRI with certain compounds such as Rapamycin, Quercetin, corticosteroids, and cortisol, due to potential interactions that might diminish the peptide's senolytic efficacy

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