In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%
Even in these studies including patients without overweight or obesity, significant weight loss was observed
Pull back the plunger to the amount you need to inject (creates air space)
fraud/omission and misrepresentation claims may proceed when tied to the FDA-approved labels or consumer weight-loss messaging, but theories based on vague extra-label communications and several other counts were dismissed with leave to amend (including UPL/PLA buckets, general negligence, and medical monitoring)
Another significant benefit is improved recovery after effort