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GLP-1 receptor agonists like semaglutide and tirzepatide typically should be paused 3-7 days before major surgery to minimize gastric complications and reduce aspiration risk during anesthesia

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and stage 3, overt diabetes, according to the American Diabetes Association ( Glucagon peptide-1 receptor agonists were approved for type 2 diabetes treatment (twice-daily exenatide) in 2005, with many long-acting classes developed in the following years

An RCT in 50 infertile men found that NAC (600 mg/day for 3 months) significantly improved sperm concentration, motility, and morphology and reduced oxidative stress markers (Ciftci et al., Urology, 2009) [69]