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Third, several of the differentially expressed proteins identified in our study have also been associated with BMI in a previously published observational study using the Olink affinity-based assay 64 , which supports our findings

Major published semaglutide trials Trial STEP 1 (Wilding et al., NEJM 2021) Design Phase 3 / 68 weeks Population 1,961 adults with obesity, no diabetes Key result -14.9% body weight (semaglutide 2.4 mg) vs -2.4% placebo

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