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Additionally, GLP-1 receptors are present in areas of the brain that control appetite and nausea, particularly in the area postrema, which is involved in the vomiting reflex

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The induction of diabetes and CKD using STZ and adenine, respectively, in the experimental animals resulted in significant hyperglycemia, weight loss, polyuria, impaired renal function and structure, and increased oxidative stress accompanied by a compromised antioxidant defense system and dysregulated inflammatory markers

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doi: 10.1158/1055-9965.EPI-11-0279