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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

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This translated into a significantly higher likelihood of achieving the conventional glycemic target of HbA1c 30, those randomized to tirzepatide experienced 36 adjudicated cardiovascular deaths or heart failure worsening events versus 56 in the placebo group, representing a 38% reduction primarily driven by fewer heart failure exacerbations

A study has shown that high expression of DPP-4 is not only found in intestinal epithelial brush border, but also in endothelial cells ( via renal elimination