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5,7 It is safe in patients with hepatic and renal impairment and is considered to be well-tolerated

This is a ratio of myoinositol: di-chiro-inositol of 100:1, compared with 0.2:1 in women with PCOS

However, the effects of berberine on neurodegenerative diseases are rarely reported and further investigation is still needed

Critics and access advocates, including organisations like I-MAK, argue that this strategy is designed to create a legal moat so wide and deep that any generic competitor must spend decades and billions challenging individual patents in court, making market entry financially prohibitive

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