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Addressing insulin resistance or thyroid imbalances may enhance the benefits of GLP-1 therapy, as these factors are associated with improved metabolic outcomes

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The reduction in right ventricular end-diastolic area (RVEDA) and the improvements in right ventricular fractional area change (RVFAC) and tricuspid annular plane systolic excursion (TAPSE) suggest that semaglutide not only attenuates RV dilation but also enhances the contractile function of the RV