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Should I use them
Key Points Semaglutide causes diarrhea through multiple mechanisms slowing stomach emptying while speeding up colon activity and affecting nutrient absorption Higher semaglutide doses used for weight loss (Wegovy) cause more GI issues than diabetes doses (Ozempic) Most people see improvement over time as their body adapts to the medication The diarrhea doesn't mean the drug is "working better" Starting semaglutide (Ozempic or Wegovy) can be an exciting development in your diabetes or weight loss journey
The mechanism is likely multifactorial: enhanced dehydration from the medication, delayed alcohol absorption leading to extended blood alcohol exposure, and altered sleep quality
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This results in increased TCA cycle activity and sufficient substrate availability for NRF2-regulated enzymes that require TCA cycle intermediates
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