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Dependence Both tolerance and physical dependence can develop during use of opioid therapy
Most patients begin noticing improvements in pain and function within 2-4 weeks
The lack of specific ferroptosis markers drives the necessity to determine ferroptosis in a complex way, which includes morphological, biochemical, and genetic hallmarks as well as evaluation of degradation and upregulation of certain proteins [217]
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Firstly, motor neurological signs ( greater impairment in sensory processing tasks
