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First, diabetes blunts weight loss by roughly 6 to 7 percentage points versus non-diabetic obesity at the same dose, because long-standing high glucose dampens the metabolic cascade the drug works through. Second, the 10-to-15 mg step keeps adding weight loss in every band

Key Takeaway: Effectiveness in supplementation is measured by cellular uptake, not milligram weight

During exercise, serotonin levels rise and can make you feel more fatigued, meaning you won't be able to push as hard

Granseth B, Andersson FK, Lindstrm SH

Stomach acids will break down B-12 taken orally, limiting the amount of usable B-12 your body will be able to absorb