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REDEFINE 2 included 1,206 participants with overweight or obesity and type 2 diabetes

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This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance

Researchers are investigating whether NNMT inhibition modulates the cellular metabolic responses to repeated contractile stress, potentially explaining the differential metabolic profiles observed when combining NNMT inhibition with exercise protocols in research models

Proc Natl Acad Sci USA 99 : 77467750