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The present study assessed the potential hepatoprotective effects of phytic acid (PA), a natural antioxidant and iron chelator, on APAP-induced hepatotoxicity and the possible underlying mechanism through its effects on CYP2E1 gene expression, iron homeostasis, oxidative stress, and SIRT -1 expression levels

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For these purposes, Microsoft Excel (Microsoft Corp.), XLSTAT 2014 for MS Excel (Addinsoft SARL) and IBM SPSS Statistics 20.0 (IBM Corporation) programs were used, thus creating databases used in the present research (3,9,11)