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Animal model research in the published literature has explored dermal and connective tissue applications using topical or localized administration protocols in rodent models
Sikiric, P., Kokot, A., Kralj, T., Zlatar, M., Masnec, S., Lazi, R., Lonari, K., Oroz, K., Sabli, M., Boljesic, M., Antunovi, M., Sikiri, S., trbe, S., Stambolija, V., Orekovi, B., Kavelj, I., Novosel, L., Zubcic, S., Krezic, I., krti, A., Jurjevi, I., Blagai, B., Seiwerth, S., & Stareini, M
This can be due to folate receptor autoimmunity (FRA), which blocks folate transport across the blood-brain barrier
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