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Seropositive AIH is usually classified based on the autoantibody profile: type 1 AIH is labeled in the presence of ANA or ASMA antibodies, while type 2 AIH is diagnosed in the presence of LKM-1 or anti-LC-1 antibodies [9, 42, 50, 53]

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Specifically, increased expression of peroxisome proliferator-activated receptor- coactivator-1 protein, a key regulator of mitochondrial biosynthesis, disrupts the mitochondrial structure and leads to dysfunctional proliferation, which is involved in the development of certain cardiac diseases, such as heart failure and atherosclerosis (45)

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