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Unlike Ozempic/Wegovy, this is a dual agonist of GLP-1 and another intestinal peptide called GIP and trials point to greater efficacy in terms of weight loss, with a similar safety and tolerability profile

Abbreviations: T2DM, type 2 diabetes mellitus

Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)

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