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Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks

10.2174/1381612826666200424180139 [DOI] [PubMed] [Google Scholar] Sikiric P., Hahm K

However, GHRP-6 also activates ghrelin receptors in the hypothalamus and peripheral tissues driving the appetite stimulation, cortisol elevation, and prolactin increase associated with its use

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