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Retinoic acid and immune homeostasis: a balancing act

The takeaway is that glutathione biology is well understood, while the clinical picture for supplementation is still developing

When the concentration of the lipid peroxidation product 4-HNE is relatively low, it can augment IKB kinase (IKK) activity, promoting IKB phosphorylation

Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than an optimum level of glutathione is observed in individuals experiencing a decline in cognitive function.* Conversely, individuals who live to 100 tend to have higher glutathione activity.*