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In a study where subjects underwent esophageal sampling along with a validated food frequency questionnaire to quantify dietary fiber and fat intake, findings showed that increased fiber intake was significantly associated with increased relative abundance of thick-walled phyla and decreased relative abundance of overall G- bacteria, including Prevotella, Neisseria , and Eikenella ( 2.2.2 Altered esophageal microbiome is strongly associated with GERD In 2009, Yang et al