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The idea is to use the lowest effective dose to prevent regain without the side effects associated with higher therapeutic doses

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The future of anti-amyloid trials

Every escalation decision is reviewed by an independent Safety Review Committee, which evaluates all available data against predefined stopping rules

In conclusion, we revealed novel structurefunction relationships of glutaredoxins, gained insights regarding the enzymatic conversion of glutathione- and non-glutathione disulfide substrates, and identified two distinct substrate interaction sites that include a scaffold residue and the conserved dual activator Lys105 in ScGrx7 and Lys26 in PfGrx