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In general, oxidative stress results from the abnormal production of ROS and the loss of cellular antioxidant capacity

Ann Intern Med 151(9):650661 Ventimiglia E et al (2016) The safety of phosphodiesterase type 5 inhibitors for erectile dysfunction

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The primary and most prevalent isoform, however, is the shorter isoform A ( via the inhibition of NOTCH1 signaling