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Earlier anti-obesity medications primarily targeted appetite suppression or fat absorption but were often limited by modest efficacy and significant safety concerns, including cardiovascular and psychiatric adverse effects

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DSIP, or Delta Sleep-Inducing Peptide, is a naturally occurring neuropeptide that has been studied for possible effects on sleep regulation, stress response, and neuroendocrine function

And the 12 mg group lost 24.2%, averaging 27.2 kg (approximately 60 pounds) of weight reduction

Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice