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Furthermore, the need for long-term medication can result in adverse effects, including chronic kidney damage 7

Similarly, will human subjects with prediabetes, or those at low risk for cardiovascular disease, be suitable candidates for GLP-1R agonism without long-term data establishing durability and reduction of complications

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This efficacy suggests the drug could be suitable for patients with greater weight loss needs, including as an alternative to more invasive treatments like bariatric surgery

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