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Throughout the experimental period, animals were monitored daily for signs of distress, including severe lethargy, impaired mobility, abnormal posture, or inability to access food and water

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

Semaglutide, meanwhile, interacts only with the GLP-1 receptor

This includes maintaining a consistent sleep schedule, creating a restful sleeping environment (cool, dark, and quiet), avoiding stimulants like caffeine and nicotine close to bedtime, and limiting exposure to screens before sleep

Participants on semaglutide lost an average of approximately 14.9% of body weight at 68 weeks compared with placebo