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Efficacy and safety of once-weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3): A 56-week, open-label, randomized clinical trial

Peak anti-inflammatory benefit appears to coincide with the period of most active weight loss (months 3 through 9), though improvements persist as long as treatment continues

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Patients in the STEP trials lost an average of 10-15% of their body weight and even losing a small amount of weight can lower blood pressure or prevent it from rising

Expired semaglutide is not acutely toxic, but potency is compromised, reducing therapeutic benefit