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The cancer biology concerns make extended use particularly uncertain

Collagen peptides taken orally are the most familiar example

*Correspondence: Hui Chen [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Most studies report an increased sensitivity to experimental pain and, therefore, a decreased pain threshold in depressed compared to non-depressed subjects especially when emotional aspects of experimental pain are taken into account (Ushinsky et al., 2013)