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Understanding the impact of renal or hepatic impairment on the pharmacokinetic properties of cagrilintide is crucial for managing overweight and obesity in individuals with these conditions, particularly as chronic kidney disease and liver disease including metabolic dysfunction-associated steatotic liver disease are common comorbidities of obesity

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In preclinical cell-based models, hCG is used to interrogate Leydig cell responsiveness, CYP enzyme induction kinetics, and receptor desensitisation and internalisation dynamics

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Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials