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Activation of hepatic GPER1 leads to cAMP release and AMPK-mediated signaling (11), and activation of membrane-bound ER triggers the protein kinase A-liver kinase B-AMPK signaling pathway, increasing phosphorylation of ACC and SREBP1 (20)
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Clinical trials didnt see double-digit percentage weight drops until participants reached 1.7 mg and stayed there for at least 12 weeks (Rubino et al., JAMA 2021)
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