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A direct comparison of P5 with the reference peptide Ex4 revealed that G-protein signalling downstream of GLP-1R activation in the absence of -arrestin signalling is sufficient to correct hyperglycaemia, improve insulin sensitivity, preserve pancreatic islet integrity and improve liver steatosis

The tendency for increased t 1/2 with increasing renal impairment was not considered clinically relevant, as exposure was similar between groups, and results supported once-weekly SC administration of cagrilintide

doi: 10.1101/GAD.314674.118 41 KurutasEB

This transient elevation is attributable to the immaturity of carnitine transport and utilization mechanisms in preterm infants (38, 39)