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How Much Weight Loss Do Clinical Trials Show: Retatrutide vs Tirzepatide Weight Management Research Data Phase 3 clinical trial data places retatrutides average body weight reduction at approximately 28% over 18 months, a figure that Eli Lilly and independent commentators have described as comparable to outcomes typically associated with bariatric surgery [2]

doi: 10.1016/j.tem.2024.07.012 Summary Keywords glucagon-like peptide-1, type 2 diabetes mellitus, l-cell, metabolic surgery, jejunostomy Citation Wang S, Yuan C, Wang H, Ye X, Ruan S, Yi L, Yang W, Wang Z, Wang N, Li J, Feng X, Li Y, Tian Y and Wang Q (2026) Research progress in precision medicine for type 2 diabetes based on the GLP-1

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