Tuy nhin, khng t loi kem chng nng trn th trng c cha cn, d gy kh da hoc kch ng cho nhng ngi c ln da nhy cm
doi: 10.1590/S1677-5538.IBJU.2015.02.07 77 KessopoulouEPowersHJSharmaKKPearsonMJRussellJMCookeIDet al
The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
177 SHANKs were first implicated in ASD by studies on PhelanMcDermid syndrome, 200,201 a neurodevelopmental disorder caused by 22q13.3 deletion, and are deleted in almost all reported PhelanMcDermid syndrome cases
Finally, we highlight major limitations in the current evidencesuch as heterogeneous dosing regimens, the scarcity of long-term clinical data, and insufficient mechanistic validation under MASLD conditionsand propose directions for future translational research
