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PMID 23020132

IV infusion (clinic-based) Protocol: Continuous daily supplementation -- typically 250-1000 mg NMN or 300-600 mg NR per day Rationale: NAD+ depletion is continuous, requiring ongoing replenishment to maintain elevated levels Requirements: No special handling for oral supplements

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Typically, only one Phase 2 proposal is awarded per Phase 1 award

These observations are consistent with a crossover study in 20 adults reporting significantly higher fasting plasma TMAO in participants above median age (45.5 years) ( Phase II data revealed an age group sex interaction on the intervention effects, indicating that the effect of the pomegranate extract on TMAO reduction varied by the combination of age and sex