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The coenzyme NADPH differs from nicotinamide adenine dinucleotide (NADH) only by the presence of a phosphate group on one of the ribose units

Grippaudo FR, Di Russo PP

Genetic knockout (KO) of Rac1 in excitatory neurons in mice resulted in decreased spine and synapse numbers accompanied by increased postsynaptic density (PSD) ( in vitro through constitutively active Rac1 in cultured hippocampal slices leads to increased spine density but reduced spine size (Nakayama et al., 2000

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Low levels of reactive oxygen species (ROS) mediate signaling cascades involved in cell proliferation [8], while high ROS levels can lead to DNA damage and eventual cell death [9]