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Reported adverse effects in human supplementation trials are rare but may include gastrointestinal discomfort, skin pigmentation, and hormonal modulation at higher doses ( 11 Conclusion Astaxanthin has emerged as a uniquely versatile carotenoid with potent antioxidant, anti-inflammatory, and mitochondrial-supporting properties that distinguish it from many conventional antioxidants

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Researchers have stated that oral contraceptives alter tissue uptake patterns, thus the distribution of the vitamin

It may also interact with nitric oxide pathways that affect blood vessels and inflammation

Use of supplement oxygen is not prohibited