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These compounds, especially naringin and hesperidin, have been found to inhibit starch hydrolyzing enzymes (alpha-amylase and alpha-glucosidase) and glucose transporters (GLUT2) to reduce carbohydrate digestion and absorption in the intestine, which in turn lead to a reduction of glucose release into the bloodstream and attenuation of postprandial hyperglycemia

found that in colon cancer, Gln deprivation stimulates p53 activation and promotes the expression of the aspartate/glutamate transporter SLC1A3, thereby promoting glutamate, Gln and nucleotide synthesis, maintaining electron transport chain and tricarboxylic acid cycle activity

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44 Changes in glycaemic status (shift from prediabetes to normoglycaemia